Cristiano Ronaldo will return, while Casemiro will make his first start for Manchester United against Real Sociedad on Thursday night.
La Liga champions Real Madrid are reportedly considering 21-year-old Brazilian midfielder Joao Gomes as an option to replace Casemiro.
Casemiro and Cristiano Ronaldo are on the bench, as the starting eleven remains unchanged for Manchester United's meeting with Southampton.
Cristiano Ronaldo is set to return, while Casemiro will make his Manchester United debut against Southampton on Saturday.
Manchester United will hope to build on this week's win over Liverpool when they take on Southampton at St. Mary's on Saturday.
Liverpool legend Graeme Souness has claimed that Manchester United's latest signing Casemiro has never been a great player in his career.
Real Madrid will reportedly look to sign 27-year-old Danish midfielder Pierre-Emile Hojbjerg from Premier League club Tottenham Hotspur in a late move this summer.
Manchester United have confirmed that they have reached an agreement to sign Casemiro from Real Madrid.
Casemiro is reportedly inching closer to joining Manchester United from Real Madrid in a blockbuster £60 million move this summer.
English giants Manchester United have submitted an enquiry to Real Madrid for Casemiro while offering a five-year contract to the Brazilian midfield powerhouse.