Callum Hudson-Odoi misses out with an injury but N'Golo Kante and Antonio Rudiger should return to the lineup when Chelsea face Newcastle United.
Lewis Hall was the standout performer as Chelsea cruised to a 5-1 win over Chesterfield in the FA Cup third round on Saturday.
Lazio manager Maurizio Sarri has reportedly set his sights on Chelsea forward Callum Hudson-Odoi in the January transfer window.
Jorginho is ruled out, but Callum Hudson-Odoi and Cesar Azpilicueta will return when Chelsea and Zenit St Petersburg face off on Wednesday.
Reece James and Trevoh Chalobah stole the show as Chelsea thrashed Juventus 4-0 to book a place in the knockout stages of the UEFA Champions League.
Barcelona are reportedly keeping a close eye on three of Chelsea's prized attackers in Christian Pulisic, Hakim Ziyech and Callum Hudson-Odoi.
Ross Barkley, Callum Hudson-Odoi and Kai Havertz made their mark as Chelsea were held to a 1-1 draw by Burnley at Stamford Bridge on Saturday.
Bundesliga giants Borussia Dortmund are reportedly keeping tabs on three Chelsea players including Christian Pulisic.
Mason Mount and Callum Hudson-Odoi were among those who dazzled as Chelsea cruised to a 7-0 win over Norwich City on Saturday.
Callum Hudson-Odoi and Reece James return but Cesar Azpilicueta has been benched as Chelsea prepare to take on Norwich City at Stamford Bridge.