Cristiano Ronaldo scored again but it was not enough for ten-man Manchester United to grab even one point, as BSC Young Boys handed them a 2-1 loss on Tuesday.
Victor Lindelof comes in for Raphael Varane while Donny van de Beek makes a rare start as Manchester United prepare to take on BSC Young Boys in Bern.
Fred is likely to replace Nemanja Matic while Cristiano Ronaldo will start again when Manchester United face BSC Young Boys on Tuesday.
Manchester United will hope to begin their UEFA Champions League campaign on a strong note when they take on BSC Young Boys on Tuesday.
Arsenal and Liverpool are reportedly among clubs keeping a close eye on Young Boys' defensive prodigy Mohamed Ali Camara ahead of the summer transfer window.
Juventus are still in danger of losing their top spot in Group H of the UEFA Champions League and will hope to lock it down with a win away at BSC Young Boys.
An injury-time strike from Marouane Fellaini fired Manchester United to a narrow win over BSC Young Boys at Old Trafford on Tuesday night.
Manchester United manager Jose Mourinho has made as many as six changes to the team that started against Crystal Palace, for their UEFA Champions League game against BSC Young Boys.
Jose Mourinho is likely to be forced into making a few changes, when Manchester United face off against BSC Young Boys on Tuesday night.
After a disappointing weekend, Manchester United will be looking to bounce back strongly when they face off against BSC Young Boys in the Champions League