With top spot in Group C already sealed, Barcelona boss Luis Enrique had the freedom to field a much changed line-up from the Clasico against a beleaguered Borussia Mönchengladbach side that had last tasted victory back in October.
Ten-man Juventus took a step towards the Champions League knockout phase with a 1-1 draw at Borussia Moenchengladbach on Tuesday as Stephan Lichtsteiner scored on his return from heart surgery.
Gabon striker Pierre-Emerick Aubameyang netted a hat-trick on Sunday as Borussia Dortmund ran riot in a 5-1 home win over bottom side Augsburg to stay second in the Bundesliga.
Sergio Aguero's 90th-minute penalty sealed Manchester City's 2-1 comeback win at Borussia Moenchengladbach on Wednesday in the Champions League to continue the Germans' spot-kick misery in Europe.
Liverpool and Manchester United were keeping tabs on German midfielder Christoph Kramer who is currently on loan at Borussia Mönchengladbach from Bayer Leverkusen.