Defending Champions Chelsea head to the King Power Stadium, where they will face Craig Shakespeare's Leicester City in the first of their seven games this month.
Sitting with a nine point lead at the top of the table, the Catalans are eyeing a second successive treble while Real have their sight firmly fixed on the Champions League trophy after dropping out of the title race.
With El Clasico looming large on the horizon, Real Madrid manager Zinedine Zidane is set to host 5th placed Sevilla in what promises to be an exciting clash in the Spanish La Liga.
The second leg of the round of 16 Europa League tie between Tottenham Hotspur and Borussia Dortmund promises to be an exciting clash, with the German side in a commanding position after a 3-0 home win in the first leg last week.
Real Madrid host 13th placed Espanyol as they look to close the gap with Barcelona and Atletico Madrid at the top of the table.
Looking to maintain his 100% win record since taking over the reins from Rafael Benitez, Zinedine Zidane and his team travel to Real Betis in a bid to keep up Barcelona and Atletico Madrid in the Spanish La Liga.
