N'Golo Kante will likely be replaced by Ruben Loftus-Cheek, while Timo Werner and Marcos Alonso could start when Chelsea take on Manchester United.
Chelsea registered a comfortable victory over Leicester City, with Antonio Rudiger, NGolo Kante and Christian Pulisic getting the job done
Mason Mount, Reece James and Ben Chilwell are set to return when Chelsea welcome Burnley to Stamford Bridge on Saturday.
Cesar Azpilicueta and Marcos Alonso return while Ben Chilwell has been given a breather as Chelsea prepare to take on Malmo.
Chelsea will be aiming to consolidate their position at the top of the Premier League table when they travel north to take on Newcastle United this weekend.
Mason Mount and Callum Hudson-Odoi were among those who dazzled as Chelsea cruised to a 7-0 win over Norwich City on Saturday.
Ben Chilwell and Edouard Mendy were pivotal figures as Chelsea eked out a narrow 1-0 win over a resolute Brentford on Saturday.
England kept their lead intact on top of Group I with a more than convincing 5-0 victory over minnows Andorra
Timo Werner and Trevoh Chalobah stood out as Chelsea clinched a hard-fought 3-1 win over Southampton at Stamford Bridge on Saturday.
Timo Werner, Ben Chilwell and Mason Mount will return to the starting lineup when Chelsea welcome Southampton to Stamford Bridge on Saturday.