Anthony Martial and Luke Shaw will be unavailable when Manchester United go head-to-head with Southampton at St. Mary's on Saturday.
Manchester United defender Ashley Young is reportedly being linked with a summer move to MLS side DC United.
Manchester United were booted out of the UEFA Champions League as Barcelona handed them a 3-0 defeat at Camp Nou on Tuesday.
Manchester United tasted their fourth defeat in five matches as Barcelona beat them 1-0 in the first leg of the UEFA Champions League quarter-final.
Manchester United suffered a major blow to their top four hopes as Wolves came from behind to beat them 2-1 at Molineux on Tuesday night.
Ole Gunnar Solskjaer has made five changes to the side that eased past Fulham last weekend as Manchester United prepare to take on PSG in the UEFA Champions League.
Veteran defender Ashley Young has signed a new one-year deal with Manchester United that will keep him at the club till the summer of 2020.
Manchester United returned to winning ways in the Premier League, as they thrashed Claudio Ranieri's Fulham 4-1 at Old Trafford on Saturday.
The Hard Tackle provides a throwback to five of the top highlights for Manchester United in 2017 and the year that was
Manchester United had Jesse Lingard to thank as they came from two goals down to hold Burnley to a 2-2 draw at Old Trafford on Boxing Day