Ernesto Valverde will be without Jordi Alba, who injured his hamstring in training as he prepares his Barcelona side for Olympiacos in the Champions League.
David Silva's 13th minute goal was the pick of the bunch, and left the Spanish fans in attendance dazed at the quality of the overall build-up.
Barcelona secured a 3-0 win away at Osasuna, thanks to a second half-brace from Lionel Messi after Luis Suarez opened the scoring for the visitors.
Barcelona swept aside Osasuna with a comfortable 3-0 victory at El Sadar Stadium to keep the pressure up on league leaders Real Madrid
Those 'individual battles' will be hard fought, as Sevilla will surely be desperate to take advantage of a crippled Barcelona side who are just coming off a 3-1 thrashing against Manchester City in the Champions League.
Barcelona humbled former manager Pep Guardiola with a 4-0 win against his Manchester City team at Camp Nou. However the victory wasn't without any casualties.
Pep Guardiola tried to woo four Barcelona stars in the summer.
Arsenal's Hector Bellerin, who has been linked with a move to Barcelona and Manchester City, is reportedly available for a minimum of €35m.
New signings Samuel Umtiti and Denis Suarez handed their first league start as Barcelona take on Real Betis at Nou Camp for the season opener.
The latest El Clasico proved to be another reminder of why the fixture is so named. Even though Barcelona took the lead in the second half, Real Madrid triumphed 2-1 at Camp Nou.