Adrian was the catalyst of the late capitulation as Liverpool were booted out of the UEFA Champions League by Atletico Madrid on Wednesday.
Fabinho was underwhelming again as a sub-par Liverpool were booted out of the FA Cup after being handed a 2-0 defeat by Chelsea on Tuesday.
Adam Lallana and Joe Gomez return while Adrian starts in goal as Liverpool get set to take on Chelsea in the FA Cup fifth round at Stamford Bridge.
Adrian is set to replace the suspended Alisson Becker when Liverpool welcome Everton in the first Merseyside derby of the season at Anfield on Wednesday.
Liverpool will be looking to continue their unbeaten start to the season when they welcome Everton to Anfield for the 285th Merseyside derby on Wednesday.
James Milner scored the winner deep into injury time as Liverpool continued their perfect start to the Premier League season with a 2-1 win over Leicester City.
Joel Matip and Adrian were the heroes at the back as Liverpool handed a narrow 2-1 defeat to Chelsea at Stamford Bridge on Sunday.
Liverpool were handed their first defeat of the season as late goals from Dries Mertens and Fernando Llorente saw Napoli hand them a 2-0 loss at San Paolo.
Goals from Sadio Mane and Roberto Firmino fired Liverpool to a victory against Southampton, despite Adrian's howler late in the game.
Jurgen Klopp has named an expected lineup, with the only surprise that Adrian is fit enough to start in goal for Liverpool against Southampton.