James Milner will don the armband while Divock Origi will replace Sadio Mane when Liverpool take on Chelsea in the FA Cup on Tuesday.
Fikayo Tomori returns while Pedro comes in for Ross Barkley as Chelsea get set to take on Bournemouth at the Vitality Stadium.
Chelsea midfielder N'Golo Kante is back into the starting XI for their away game against Newcastle United, replacing Ross Barkley.
Mateo Kovacic comes into the Chelsea starting lineup in place of Ross Barkley as the Blues prepare to take on Ajax in their third Champions League encounter.
Frank Lampard takes charge of his first Premier League game as the Chelsea manager against arch-rivals Manchester United at Old Trafford on Sunday.
Eden Hazard is on the bench, with Maurizio Sarri making seven changes to his most recent side as Chelsea prepare to take on Slavia Praha at the Eden Arena.
Gonzalo Higuain makes his Chelsea debut as part of a much changed side as the Blues gear up to face Sheffield Wednesday in the FA Cup at Stamford Bridge.
Olivier Giroud is among three changes made by Maurizio Sarri to the side that was beaten by Arsenal as Chelsea prepare to host Tottenham in the Carabao Cup semi-final.
Leon Bailey's stepfather Craig Butler has claimed that Chelsea have inquired about the young talent and that he is unhappy at Bayer Leverkusen.
Maurizio Sarri has made eight changes to the side that beat Nottingham Forest last week as Chelsea prepare to take on Tottenham in the Carabao Cup.