Two of the tournament favourites will clash in Rio de Janeiro on Monday night, as Chile take on Uruguay in their final 2019 Copa America Group C encounter.
Top spot in Group A of the 2019 Copa America will be on the line when Brazil and Peru meet at Arena Corinthians on Saturday.
Chile will be looking to make it two wins in two matches in the 2019 Copa America, when they face off against Ecuador at the Fonte Nova Arena on Friday night.
Uruguay will be hoping to book their place in the quarter-finals of the 2019 Copa America when they take on Japan at Arena do Gremio.
Argentina will be looking to bounce back from their defeat to Colombia when they go up against Paraguay in Copa America 2019 on Wednesday.
Colombia take on 2022 World Cup hosts Qatar in their second Group B encounter as they look to extend their lead at the top and take control of the group.
Brazil will look to make it two wins in a row when they host Venezuela at the Fonte Nova Arena in Salvador in the 2019 Copa America group stage.
Reigning champions Chile will begin the defence of their Copa America title against guest nation Japan at Estadio do Morumbi on Monday night.
The first fixture of the Group C of the 2019 Copa America will see Uruguay take on Ecuador at the Estadio Governador Magalhães Pinto on Sunday night.
The first marquee fixture of the 2019 Copa America is upon as Argentina and Colombia get set to square off at Arena Fonte Nova on Saturday.