Juventus are still in danger of losing their top spot in Group H of the UEFA Champions League and will hope to lock it down with a win away at BSC Young Boys.
Ajax can steal the top spot in Group D of the 2018-19 UEFA Champions League away from Bayern Munich with a win over the German giants on Wednesday.
Liverpool booked their place in the UEFA Champions League Round of 16, courtesy of a Mohamed Salah goal that ensured their 1-0 win over Napoli.
Manchester United will clash against Spanish La Liga side Valencia in their final Group H encounter of the 2018-19 UEFA Champions League.
Manchester City takes on Hoffenheim in their final group stage game with the visitors needing a point to finish their group as toppers
Real Madrid will be hoping to continue their winning run when they host CSKA Moscow at Santiago Bernabeu in a UEFA Champions League Group G tie.
A place in the Round of 16 will be up for grabs when Shakhtar Donetsk and Lyon meet in a Matchday 6 tie at the Olympic Stadium in Kiev on Wednesday
Borussia Dortmund still have a narrow chance of topping Group A of the 2018-19 UEFA Champions League as they face bottom-placed AS Monaco.
Inter Milan will be hoping to secure a place in the UEFA Champions League Round of 16 when they welcome PSV Eindhoven to San Siro on Tuesday.
Barcelona will face off against Premier League heavyweights Tottenham Hotspur in their final Group B game of the 2018-19 UEFA Champions League.