Hector Bellerin is expected to start while Nicolas Pepe and Mesut Ozil are in line to return to the lineup when Arsenal play Everton in the Premier League.
Eric Bailly and Bruno Fernandes could return while Scott McTominay will be in contention to feature when Manchester United face Watford on Sunday.
Gareth Bale will miss out for Real Madrid while Luka Modric is expected to start in midfield when they take on Levante on Saturday night.
Barcelona manager Quique Setien will look to rest some key players against Eibar with one eye on the Champions League clash against Napoli.
Tammy Abraham and Mason Mount will start while Ruben Loftus-Cheek will be in the matchday squad when Chelsea face Tottenham on Saturday
Chelsea and Liverpool are among the Premier League clubs that are reportedly eyeing a move for Real Madrid chief scout Juni Calafat.
Barcelona have signed Martin Braithwaite from Leganes after paying his €18 million release clause, the La Liga champions have announced.
Arsenal have expressed an interest in signing Bayer Leverkusen defender Jonathan Tah, who reportedly has a release clause of €40 million
Gabriel Martinelli and Alexandre Lacazette are in line to start for Arsenal in their UEFA Europa League Round of 32 first leg tie against Olympiacos.
Odion Ighalo is set for his full Manchester United debut while Juan Mata and Victor Lindelof will return for the Europa League Last 32 first leg tie against Club Brugge.