Liverpool will be without defensive midfielder and makeshift centre-back Lucas Leiva for the visit of Manchester City on Wednesday, while French defender Mamadou Sakho will face a late fitness test.
Chelsea moved into the top half of the Premier League for the first time since August as Diego Costa sealed a 2-1 win at struggling Norwich on Tuesday.
After a morale-boosting 3-2 win against Arsenal, Manchester United prepare to continue their good run of form when they host Watford at Old Trafford on Wednesday.
Manchester City manager Manuel Pellegrini confirmed that former Liverpool winger Raheem Sterling will start against his former side on Wednesday, while midfielder Yaya Toure is a doubt after picking up a knock in the Capital One Cup final.
Chelsea interim manager Guus Hiddink named two 20-year-olds in the Blues' starting line-up against Norwich City, and both youngsters were directly involved in each of the away side's goals at Carrow Road.
Guus Hiddink expressed his displeasure at Chelsea's complacency in the second half against Norwich City, but spoke positively about setting new targets and potentially aiming for the European spots.
In a major blow for Real Madrid manager Zinedine Zidane, Croatian midfielder Luka Modric has picked up an ankle injury that will rule him out of the away fixture against Levante.
Liverpool host Capital One Cup conquerors Manchester City at Anfield on Wednesday, just three days after losing to Manuel Pellegrini's men at Wembley in a heart-breaking penalty shoot-out.
Manchester United have registered emphatic wins in their previous two fixtures and will be looking to gain another important three points against Watford at Old Trafford.
Still reeling from their derby defeat, Zinedine Zidane has a mammoth task on his hands as he looks to inspire his dilapidated, indifferent squad ahead of their away fixture against Levante.