Napoli moved joint top of Serie A after goals from Gonzalo Higuain, Vlad Chiriches and Jose Callejon saw them beat Chievo 3-1 on Saturday and get their title challenge back on track after a three-game mini-slump.
Bayern Munich remain five points clear of nearest Bundesliga rivals Borussia Dortmund after a goalless draw between Germany's top two sides on Saturday.
Struggling Atalanta will look to get their first win in 2016 as they welcome champions Juventus to the Stadio Atleti Azzurri d'Italia this Sunday.
Having won their last four games in all competitions, Manchester United will be looking to add another victory to their crown with a win against West Bromwich Albion at the Hawthorns.
Liverpool manager Jurgen Klopp has confirmed the return of defender Mamadou Sakho and attacker Daniel Sturridge for the Crystal Palace game on Sunday, but midfielder Lucas Leiva has been ruled out for up to six weeks.
Tottenham Hotspur and Arsenal played out a thrilling 2-2 draw at White Hart Lane in one of the most consequential North London derbies in recent memory, with Harry Kane once again the star for the home side.
Arsenal and Tottenham Hotspur shared the spoils in a pulsating North London derby on Saturday at White Hart Lane, with the 10-man Gunners grabbing a deserved point courtesy of a late Alexis Sánchez strike.
Real Madrid manager Zinedine Zidane praised Cristiano Ronaldo while playing down the criticism levelled against the team from the fans at Santiago Bernabeu.
Cristiano Ronaldo took Santiago Bernabeu by a storm as he scored 4 goals in the second half to lead Real Madrid to a 7-1 win over Celta Vigo.
The Italian manager, who has been widely reported to be the front runner for the Chelsea manager's job next season, is set to have one final and decisive meeting with Blues owner Roman Abramovich next week in Monte Carlo.