Lazio play host to Roma for the second Derby Della Capitale of the season. Lazio lost the reverse fixture 2-0 back in December last year thanks to a controversial penalty converted by Dzeko and a 63rd minute Gervinho goal.
Under-fire Red Devils boss Louis van Gaal has come out and said that he cannot predict his future at the club as the Manchester United board will evaluate his performance at the end of this season.
Leicester City manager Claudio Ranieri has claimed that N'Golo Kante could leave the Foxes this summer, if big teams are willing to splash out the cash for the Leicester City midfielder.
Manchester United will be hoping to get their Premier League campaign back on track when they come up against an under-performing Everton side in a high stake encounter for both sides.
The 28-year-old has had a tough time at Old Trafford since arriving in 2013, but he thinks that his association with former manager David Moyes has worsened his relationship with the Manchester United fans.
Leaders Leicester City can go seven points clear in the Premier League after closest rivals Tottenham Hotspur dropped points in a frantic 1-1 draw at Liverpool on Saturday.
Kevin De Bruyne scored on his injury comeback as Manchester City warmed up for Wednesday's Champions League quarter-final against Paris Saint-Germain by crushing Bournemouth 4-0 on Saturday.
Arsenal kept their slender Premier League title hopes alive with a 4-0 victory over Watford at the Emirates Stadium on Saturday that exacted some revenge for their FA Cup defeat by Quique Sanchez Flores's side last month.
Alexandre Pato scored on his long-awaited Chelsea debut as Guus Hiddink's experimental line-up piled more misery on Premier League bottom club Aston Villa with a 4-0 victory on Saturday.
A host of first team players are set to miss out on Saturday's clash, as Empoli look to register their first victory in Turin since 1999. Khedira and Sandro remain suspended, with Dybala and Barzagli likely to miss out with minor injuries for the hosts.