Hector Bellerin is set to make his first Premier League appearance of the season when Arsenal take on Leicester City at the King Power Stadium.
Frank Lampard has opted to prefer Reece James on the right side of the back four to start for Chelsea as they play hosts to Crystal Palace.
Arsenal manager Unai Emery has opted for a three-man backline for his side's UEFA Europa League contest against Vitoria SC on Wednesday evening.
Chelsea manager Frank Lampard has made just one change to the side that defeated Watford at the weekend for the Champions League clash against Ajax.
Roberto Firmino and Sadio Mane are among those who have been benched, while Divock Origi starts for Liverpool as they welcome Genk to Anfield.
Emerson Palmieri returns for the first time since September while Callum Hudson-Odoi is benched again as Chelsea take on Watford at Vicarage Road.
Jurgen Klopp has handed Adam Lallana a rare start in the Liverpool midfield as the Reds look to continue their unbeaten start when they face Aston Villa.
Mesut Ozil makes his second Premier League start of the season while Nicolas Pepe has been benched as Arsenal get set to take on Wolves.
Anthony Martial leads the line for Manchester United while Marcus Rashford and Victor Lindelof are fit to start as they get set to face Bournemouth.
Mesut Ozil makes his long-awaited return to the starting eleven while Hector Bellerin is the Arsenal skipper, for their Carabao Cup tie against Liverpool.