Arsene Wenger has chosen to bench Sead Kolasinac, with Nacho Monreal returning to the starting eleven as they face AC Milan in the UEFA Europa League.
Antonio Conte has made two changes to the side that beat Crystal Palace last weekend as Chelsea prepare to face Barcelona at Camp Nou for their Round of 16 second leg tie.
Jose Mourinho has chosen Marouane Fellaini to start in midfield, with Paul Pogba on the bench as Manchester United take on Sevilla in the Champions League.
Arsene Wenger has chosen not to start Aaron Ramsey and Jack Wilshere as Arsenal go up against Watford in the Premier League.
Antonio Conte has made four changes to the side that was beaten by Manchester City last weekend as Chelsea prepare to face Crystal Palace
Mohamed Salah has been reinstated into the starting lineup by Jurgen Klopp as Liverpool take on Manchester United at Old Trafford.
Marcus Rashford has been handed a start while Paul Pogba misses out as Manchester United take on Liverpool in the Premier League.
Arsene Wenger has made three changes to the side that lost Brighton last weekend as Arsenal prepare to face AC Milan at San Siro in the Europa League Round of 16 first leg
Adam Lallana returns to the starting lineup for Liverpool as they face FC Porto in the second leg of their UEFA Champions League Round of 16 tie.
Jesse Lingard returns to the starting lineup replacing Anthony Martial, who drops to the bench, as Manchester United take on Crystal Palace.