Fabinho and Thiago are fit to start while Mohamed Salah returns to the lineup as Liverpool get set to face Real Madrid in the UEFA Champions League final.
Mikel Arteta has made essential changes to the Arsenal lineup as Rob Holding replaces Ben White, while Gabriel Martinelli is preferred to Emile Smith Rowe.
Saul Niguez and Kenedy are surprise starters, while Ben Chilwell is in the matchday squad for Chelsea's game against Watford at Stamford Bridge.
Mohamed Salah and Virgil van Dijk are only fit enough to start on the bench, but Luis Diaz returns as Liverpool prepare to take on Wolves at Anfield.
Arsenal boss Mikel Arteta has started with his preferred centre-back partnership against Newcastle United, while Nuno Tavares and Emile Smith Rowe return.
Bukayo Saka is fit to start, and Ben White is on the bench against Tottenham as Arsenal manager Mikel Arteta fields a back three with Takehiro Tomiyasu.
Mikel Arteta has made one change for the Leeds United clash, with Cedric Soares coming in at left-back in place of Nuno Tavares.
Romelu Lukaku and Christian Pulisic return, but Mason Mount is benched for Chelsea's Premier League clash with Wolves at Stamford Bridge.
Juan Mata replaces Marcus Rashford while Fred is back on the bench as Manchester United face Brentford in the Premier League.
Arsenal have rung in the changes to their team with Rob Holding, Takehiro Tomiyasu and Gabriel Martinelli coming into the side.
