Trent Alexander-Arnold has been given a breather by Jurgen Klopp as Liverpool get set to lock horns with Burnley at Anfield.
Victor Lindelof has been cleared fit to start for Manchester United as the Red Devils take on Aston Villa later this evening.
Alexandre Lacazette gets recalled to the starting lineup in place of Eddie Nketiah, while Hector Bellerin also starts against Leicester City.
Billy Gilmour makes only his second Premier League start as Chelsea get set to lock horns with Crystal Palace at Selhurst Park.
Divock Origi and Alex Oxlade-Chamberlain return while Jordan Henderson is rested as Liverpool prepare to take on Aston Villa at Anfield.
Paul Pogba starts two successive games for the first time since the resumption of Premier League as Manchester United prepare to take on Bournemouth.
Pierre-Emerick Aubameyang is among four players returning to the starting lineup, as Nicolas Pepe and Bukayo Saka drop to the bench for Arsenal's league game against Norwich.
Bruno Fernandes has surprisingly not been rested while Juan Mata and Eric Bailly get a rare start as Manchester United prepare to take on Norwich City at Carrow Road.
Granit Xhaka and Kieran Tierney return while Eddie Nketiah starts upfront as Arsenal prepare to take on Southampton at the St. Mary's Stadium.
Takumi Minamino comes into the side in place of Mohamed Salah while Andrew Robertson misses out as Liverpool get set to take on Everton.