Edinson Cavani will have to wait to make his Manchester United debut, but who all make the starting lineup against Chelsea at Old Trafford?
Hakim Ziyech has been handed his first start as Chelsea start their Champions League campaign against Sevilla at the Stamford Bridge.
Paul Pogba and Mason Greenwood miss out, but who makes the Manchester United starting lineup against Newcastle United at St. James' Park?
Thiago is set to make his long-awaited first start in the Liverpool shirt, while Sadio Mane returns to the starting XI after recovering from Coronavirus.
Adrian starts in goal for Alisson Becker while Diogo Jota makes his first Premier League start for Liverpool as they take on Aston Villa.
Eric Bailly makes his first Premier League start of the season while Donny van de Beek is benched as Manchester United face off against Tottenham.
Kai Havertz and Thiago Silva return to the starting lineup, but who else is set to take the field for Chelsea against Crystal Palace at Stamford Bridge?
Gabriel Magalhaes and Dani Ceballos return to the starting lineup for Arsenal, but who else will take the field against Liverpool at Anfield?
Diogo Jota makes his full debut for Liverpool, but who else starts against Arsenal in the Carabao Cup fourth round tie at Anfield?
Edouard Mendy will make his debut for Chelsea while Timo Werner and Ben Chilwell also start in the Carabao Cup tie against Tottenham Hotspur.