Brandon Williams starts at right-back while Scott McTominay and Odion Ighalo feature for Manchester United in their Europa League Round of 16 tie against LASK.
Harry Maguire is fit to start while Daniel James and Anthony Martial return as Manchester United get set to take on Manchester City at Old Trafford.
Billy Gilmour is set to start his first Premier League game while Kepa Arrizabalaga returns in goal as Chelsea gear up to face Everton.
Pablo Mari makes his Premier League debut while Nicolas Pepe and Pierre-Emerick Aubameyang return as Arsenal get set to take on West Ham United.
James Milner comes in at left-back for Liverpool in place of Andrew Roberston while Mohamed Salah and Roberto Firmino return to the lineup against Bournemouth.
Eric Bailly and Odion Ighalo return while Juan Mata is the Manchester United skipper as the Red Devils get set to face Derby County in the FA Cup fifth round.
Billy Gilmour makes a rare appearance in the Chelsea starting lineup while Kepa Arrizabalaga starts in goal as the Blues get set to take on Liverpool.
Adam Lallana and Joe Gomez return while Adrian starts in goal as Liverpool get set to take on Chelsea in the FA Cup fifth round at Stamford Bridge.
Anthony Martial is fit enough to start for Manchester United while Nemanja Matic and Victor Lindelof also return to the side for the game against Everton.
Joe Gomez misses out with a minor fitness concern while Alex Oxlade-Chamberlain replaces Naby Keita in midfield for Liverpool against Watford.