Mason Mount and Tammy Abraham will be making their UEFA Champions League debuts imminently when Chelsea take on Valencia at Stamford Bridge.
Roberto Firmino has returned to the starting lineup while Andrew Robertson is fit to start as Liverpool prepare to take on Napoli in the UEFA Champions League.
Unai Emery has named Mesut Ozil in the side for the first time this season, while Granit Xhaka and Dani Ceballos start in midfield for Arsenal against Watford
Manchester United boss Ole Gunnar Solskjaer has made just one change to the lineup that started against Southampton last time out for the Leicester City clash.
Antonio Rudiger is fit again and returns to the starting eleven for Chelsea as the Blues travel to Molineux to face Wolves
Roberto Firmino has been replaced by Divock Origi as Liverpool prepare to take on Newcastle United at Anfield, looking to extend their perfect start to the season.
Unai Emery has named a strong Arsenal lineup for the North London Derby against Tottenham at the Emirates with Lucas Torreira and Alexandre Lacazette starting
Jurgen Klopp has opted against making any changes to the Liverpool starting eleven that defeated Arsenal last weekend for the match against Burnley.
Chelsea manager Frank Lampard has handed academy graduate Fikayo Tomori his full Premier League debut against Sheffield United.
Juan Mata makes his first start of the season while Andreas Pereira replaces Anthony Martial as Manchester United prepare to take on Southampton at St. Mary's.