Old Trafford will brace itself for the return of Chicharito while Jose Mourinho has handed starts to Romelu Lukaku and Nemanja Matic
Antonio Rudiger is in line to make his Premier League debut while Antonio Conte has handed Jeremie Boga a start as Chelsea face Burnley.
Mohamed Salah is set to make his competitive debut for Liverpool as the Reds visit Vicarage Road to take on Watford.
Alexis Sanchez will not play for Arsenal tonight while Lacazette and Kolasinac are set to make their debuts against Leicester City
Isco starts for Real Madrid with Gareth Bale fit enough to only make the bench as Los Blancos go up against Juventus in the final of the UEFA Champions League.
Arsene Wenger has made two changes to the Arsenal side that faced Everton in their final Premier League outing ahead of the FA Cup final against Chelsea.
Jose Mourinho has picked Chris Smalling and Juan Mata to start in the crucial Europa League final against Ajax.
Chelsea will remain mostly unchanged as they get ready to lift the coveted Premier League trophy after their final game of this season.
Jose Mourinho has named a number of youngsters in his matchday squad against Crystal Palace
Daniel Sturridge and Roberto Firmino are set to start at the expense of Divock Origi as Liverpool fight to secure Champions League football against Middlesbrough.