Tottenham will hope to usurp the first leg deficit and reach the UEFA Champions League quarter-finals when they face RB Leipzig at the Red Bull Arena.
Valencia will be looking to mount an unlikely comeback when they host Serie A outfit Atalanta in the second leg of their UEFA Champions League Round of 16 tie.
Bruno Fernandes and Fred starred while Odion Ighalo got his first goal for Manchester United as they thrashed Club Brugge 5-0 in the Europa League.
Shkodran Mustafi was the sole bright spot as Arsenal slumped to a 2-1 loss to Olympiacos to be booted out of the Europa League on away goals.
Alexandre Lacazette starts upfront for Arsenal while Bukayo Saka returns as they get set to take on Olympiacos at the Emirates in the UEFA Europa League.
Odion Ighalo makes his first start for Manchester United while Scott McTominay and Eric Bailly also feature in the starting lineup against Club Brugge.
Vinicius Jr. was impressive while Dani Carvajal and Sergio Ramos failed to hold their nerve as Real Madrid were handed a 2-1 loss by Manchester City on Wednesday.
Scott McTominay is in line to start while Eric Bailly could replace Victor Lindelof when Manchester United take on Club Brugge in the UEFA Europa League.
Alexandre Lacazette is set to return while Bukayo Saka will replace Sead Kolasinac when Arsenal take on Olympiacos in the UEFA Europa League.
Arsenal will be hoping to seal safe passage through to the Round of 16 of the UEFA Europa League when they face Olympiacos at the Emirates on Thursday.