Unai Emery will ring in the changes for Arsenal's UEFA Europa League opener against Eintracht Frankfurt, with Mesut Ozil rested.
Mason Greenwood and Axel Tuanzebe will make their first starts of the season when Manchester United welcome Astana to Old Trafford in the UEFA Europa League.
Arsenal begin their third Europa League campaign in a row on Thursday with a trip to Germany, where they face Eintracht Frankfurt.
A place in the UEFA Europa League group stages will be up for grabs when Scottish giants Rangers face off against Legia Warsaw in the playoffs on Thursday.
Eintracht Frankfurt will be eyeing a comeback as they host Strasbourg in the second leg of their UEFA Europa League qualifying playoff
Chelsea trumped Arsenal 4-1 in Baku to lift the Europa League trophy for the second time in their history while crashing Gunners' Champions League hopes
A second half blitz, led by Eden Hazard, saw Chelsea beat London rivals Arsenal 4-1 to lift the 2018-19 UEFA Europa League trophy.
Unai Emery has named a strong starting lineup to face Chelsea in Baku for the Europa League Final, with Petr Cech making his final career appearance.
N'Golo Kante has been passed fit enough to start for Chelsea in their 2018-19 UEFA Europa League final against Arsenal in Baku.
Chelsea and Arsenal will lock horns against each other on Wednesday night in an all-English UEFA Europa League final at the Baku Olympic Stadium.