Juventus crashed out of the UEFA Champions League as they were beaten 2-1 by Dutch giants AFC Ajax in the quarter-final second leg at home on Tuesday night.
Manchester United were booted out of the UEFA Champions League as Barcelona handed them a 3-0 defeat at Camp Nou on Tuesday.
Liverpool manager Jurgen Klopp is likely to keep the changes to a minimum when his side travel to Portugal to face Porto in the Champions League quarter-final.
Marcus Rashford starts in place of Romelu Lukaku, with Ole Gunnar Solskjaer making three other changes for Manchester United's game against Barcelona.
Liverpool will be aiming to drive home their first leg advantage and qualify for the UEFA Champions League semi-final, when they take on Porto this week.
Manchester City will be looking to overturn a narrow deficit when they host Tottenham for the second leg of the UEFA Champions League quarter-final on Wednesday.
Alexis Sanchez is in contention to feature when Manchester United take on Barcelona in the UEFA Champions League quarter-final second leg at Camp Nou.
Lionel Messi and Luis Suarez are among a host of players that are set to return to the starting lineup when Barcelona host Manchester United at Camp Nou.
Juventus will be aiming to make it through to the semi-final of the UEFA Champions League, when they face off against AFC Ajax on Tuesday night.
A spot in the Last Four stage of the UEFA Champions League will be decided when Barcelona host Manchester United at Camp Nou in the quarter-final second leg.