Real Madrid continued their resurgent run on Wedneday as they cruised to a 5-0 win over Viktoria Plzen in a UEFA Champions League Matchday 4 tie
Manchester United welcome back Jesse Lingard while Ander Herrera comes in for Fred for the away Champions League game against Juventus.
Barcelona secured qualification to the UEFA Champions League Round of 16 on Tuesday, as they were held to a 1-1 draw by Inter Milan at San Siro
Manchester United are in need of a win as they travel to Turin to face Juventus on Wednesday in a Group H encounter in the Champions League.
Santiago Solari is without five first-team players ahead of his first UEFA Champions League tie in-charge of Real Madrid against Viktoria Plzen.
A first half brace from Milan Pavkov condemned Liverpool to a 2-0 defeat against Crvena Zvezda in the UEFA Champions League on Tuesday.
Real Madrid will hope to inch closer to sealing place in the UEFA Champions League Round of 16 when they take on Viktoria Plzen on Wednesday
Manchester City will be looking to continue on their winning ways, when they face off against Shakhtar Donetsk in the UEFA Champions League.
Liverpool manager Jurgen Klopp has made three changes to the team that started against Arsenal this weekend, for their UEFA Champions League contest against Crvena Zvezda
Ernesto Valverde is without three first-team players as Barcelona prepare to face Inter Milan at San Siro in a Group B tie of the UEFA Champions League.