Unai Emery makes five changes to the side that beat Watford on Monday with Alexandre Lacazette among those returning, while Mesut Ozil is only on the bench
One of the four semi-finalists of the UEFA Europa League will be confirmed when Valencia host Villarreal at Mestalla in the quarter-final second leg on Thursday.
Unai Emery has travelled with a strong squad to face Napoli as Arsenal eye progression to the semi-finals of the UEFA Europa League.
Arsenal holds a two-goal advantage over Napoli, although their away form in the Europa League might come back to bite them at the San Paolo
Two Eagles will lock horn against each other as Eintracht Frankfurt host SL Benfica in the 2nd leg of their quarterfinal encounter in the UEFA Europa League
Liverpool manager Jurgen Klopp has made three changes to the lineup that defeated Chelsea at the weekend, for their Champions League clash against FC Porto.
Juventus crashed out of the UEFA Champions League as they were beaten 2-1 by Dutch giants AFC Ajax in the quarter-final second leg at home on Tuesday night.
Manchester United were booted out of the UEFA Champions League as Barcelona handed them a 3-0 defeat at Camp Nou on Tuesday.
Chelsea will be looking to defend their narrow 1-0 lead from the first leg when they host Slavia Prague in the UEFA Europa League on Thursday.
Liverpool manager Jurgen Klopp is likely to keep the changes to a minimum when his side travel to Portugal to face Porto in the Champions League quarter-final.