Karim Benzema put on a show as Real Madrid defeated Deportivo Alaves on Friday night to retain their four-point lead on top of La Liga.
Brighton & Hove Albion will look to increase their gap to the relegation zone when they host Manchester City at the Amex Stadium on Saturday.
Barcelona will be looking to keep up the pace with La Liga leaders Real Madrid, when they face off against Real Valladolid on Saturday evening.
Chelsea face Sheffield United in a must-win encounter at Bramall Lane on Saturday as the battle for UEFA Champions League qualification hots up.
Liverpool will continue their record-breaking Premier League campaign against Burnley on Saturday. Will the Reds extend their perfect home record?
Paul Pogba and Mason Greenwood were the star performers as Manchester United continued their excellent form by securing a 3-0 win over Aston Villa on Thursday.
Real Madrid will look to increase their stronghold on top of La Liga when they welcome Deportivo Alaves to the Alfredo Di Stefano Stadium on Friday.
Inter Milan will be desperate to bounce back after being handed a shock defeat by Bologna last time out. Their next opponents are Hellas Verona, who will host them on Thursday.
Manchester United are eying a fifth consecutive win in all competitions as they lock horns with Aston Villa on Thursday.
A late Jamie Vardy goal cancelled out Pierre-Emerick Aubameyang's first-half strike as Leicester City held a ten-man Arsenal side to a 1-1 draw on Tuesday.