Bruno Fernandes will captain Manchester United while Amad Diallo and Marcus Rashford will be on the bench when they take on Real Sociedad in the Europa League.
Emile Smith Rowe and Martin Odegaard could start together as Arsenal face SL Benfica at the Karaiskakis Stadium in Greece.
Amad Diallo is in line to make his full Manchester United debut while Mason Greenwood and Brandon Williams should start against Real Sociedad.
AC Milan welcome Crvena Zvezda on Thursday hoping to secure a victory that could see them advance through to the Round of 16 of the UEFA Europa League.
Arsenal ‘host’ Benfica in the crucial second leg of the UEFA Europa League round of 32 fixture at the Karaiskakis Stadium in Greece on Thursday.
Oscar Mingueza may get the nod ahead of Clement Lenglet and Samuel Umtiti when Barcelona meet Elche CF on Wednesday.
Karim Benzema misses out again while Marco Asensio and Vinicius Jr. should start when Real Madrid take on Atalanta in the UEFA Champions League.
Tottenham Hotspur will be eyeing to qualify for the next phase of the UEFA Europa League when they lock horns with Wolfsberger AC in the Round of 32 second leg.
Manchester City shift their attention towards the UEFA Champions League as they travel to Budapest to face Borussia Monchengladbach in the Round of 16.
Kai Havertz and Christian Pulisic are in contention to start as Chelsea go head to head with Atletico Madrid on Tuesday.