Arsenal eye yet another home win when they host Crystal Palace as Unai Emery challenges his side to maintain their momentum in the top four race
Borussia Dortmund will be aiming to reduce the gap to the top of the table when they travel to Schwarzwald Stadion to face SC Freiburg on Sunday.
Liverpool will be aiming to reclaim pole position in the Premier League standings, when they face off against relegation battlers Cardiff City on Sunday.
Manchester United will be desperate to return to winning ways and take a grip on the top four race when they take on Everton at Goodison Park.
Both Manchester City and Tottenham Hotspur have made significant changes to their teams that started in the midweek, for their weekend clash at the Etihad.
Juventus will have another shot at confirming their 2018-19 Serie A title as they host Fiorentina at the Allianz Stadium on Saturday.
A fantastic Arsenal performance ensures a semifinal berth in the Europa League after Alexandre Lacazette scored a decisive free-kick to boot Napoli out
Ousmane Dembele is likely to come in for Philippe Coutinho when Barcelona welcome Real Sociedad to Camp Nou on Saturday.
AC Milan enter a crucial stage in their season when they take on Parma, with every game between now and the end of the season deemed a must-win
Barcelona will be looking to take another step towards defending their La Liga crown when they welcome Real Sociedad to Camp Nou on Saturday.