Inter Milan look to extend their lead at the top of the Serie A table as they lock horns with Parma at the Ennio Tardini Stadium on Thursday.
The marquee Premier League fixture this midweek will be played on Thursday at Anfield, where Liverpool will host Chelsea in a high-stakes encounter.
Tottenham Hotspur are hoping to extend their winning run to three matches in all competitions with a triumph against Fulham on Wednesday.
Barcelona will be hoping for a big turnaround in the second leg of the Copa del Rey semi-final against Sevilla, with a place in the final up for grabs.
Manchester United will be eager to bounce back to winning ways when they take on Crystal Palace at Selhurst Park on Wednesday.
AC Milan will be looking for their second straight win, when they welcome Udinese to San Siro on Wednesday night.
Paris Saint-Germain will be hoping to regain their place at the top of the Ligue 1 table when they lock horns with Bordeaux on Wednesday.
Marco Rose looks to prove himself against his future club as Borussia Monchengladbach take on Borussia Dortmund in the DFB Pokal quarterfinal.
Juventus look to rejuvenate their title challenge as they face Spezia at the Allianz Stadium on Tuesday.
Premier League leaders Manchester City will be eager to extend their record-breaking winning run when they welcome Wolves to the Etihad on Tuesday.