Liverpool will travel to St. Mary's Stadium this midweek to take on Southampton, hoping to keep the Premier League title race alive.
Arsenal aim to move into the driving seat in the race for the fourth spot in the Premier League when they visit Newcastle United on Monday night.
Juventus will look to end their disappointing campaign on a high when they take on SS Lazio in their final home game of the season.
Inter Milan will travel to Cagliari knowing very well that anything short of three points could mean kissing their chances of retaining the Scudetto goodbye.
Manchester City will be aiming to increase their lead at the top of the Premier League table when they face West Ham United this weekend.
AC Milan could move to within a game of securing the Serie A title should they defeat Atalanta at the San Siro on Sunday.
Aston Villa aims to close the season positively as they host fellow mid-table battlers Crystal Palace, seeking their third consecutive league win
Real Madrid will want to bag all three points when they travel to Estadio Nuevo Mirandilla to face Cadiz in their penultimate La Liga fixture of the season.
Barcelona will be aiming to secure second place in the league table when they take on Getafe on Saturday.
Leeds United will be desperate to bounce back to winning ways when they welcome Brighton & Hove Albion to Elland Road on Sunday.