AC Milan will be looking for their second straight win, when they welcome Udinese to San Siro on Wednesday night.
Paris Saint-Germain will be hoping to regain their place at the top of the Ligue 1 table when they lock horns with Bordeaux on Wednesday.
Marco Rose looks to prove himself against his future club as Borussia Monchengladbach take on Borussia Dortmund in the DFB Pokal quarterfinal.
Juventus look to rejuvenate their title challenge as they face Spezia at the Allianz Stadium on Tuesday.
Premier League leaders Manchester City will be eager to extend their record-breaking winning run when they welcome Wolves to the Etihad on Tuesday.
Real Madrid will be aiming to close the gap to the top of the La Liga table when they lock horns with Real Sociedad at Estadio Alfredo Di Stefano on Monday.
Diogo Jota and Fabinho set to come back into contention as Liverpool go head to head with Sheffield United on Sunday.
Thomas Partey is set to return to the starting lineup when Arsenal face Leicester City at the King Power Stadium on Sunday.
Atletico Madrid will be looking to bounce back to winning ways when they lock horns with Unai Emery's Villarreal at El Madrigal on Sunday night in La Liga.
Chelsea will be aiming to bolster their top-four hopes when they lock horns with Manchester United in Matchweek 26 of the 2020/21 Premier League on Sunday.