FC Porto are hoping to maintain pressure on league leaders Sporting CP when they take on Vitoria Guimaraes on Thursday.
Leicester City will be hoping to consolidate third place on the Premier League table when they welcome West Bromwich Albion to the King Power Stadium on Thursday.
Atletico Madrid will be hoping to strengthen their grip at the top of the La Liga table when they take on SD Huesca this midweek.
A semifinal ticket in the Coupe de France is at stakes as Olympique Lyon play hosts to AS Monaco on Wednesday.
Real Madrid will be aiming to go to the top of the La Liga table when they lock horns with Cadiz at Estadio Ramon de Carranza this midweek.
Manchester City will hope to get back to winning ways when they take on Aston Villa at Villa Park on Wednesday.
Juventus will be hoping to resurrect their faltering season when they face off against Parma at the Allianz Stadium in Serie A on Wednesday night.
Inter Milan will be hoping to take a step closer to winning the Serie A title when they take on Spezia at Stadio Alberto Picco on Wednesday.
Tottenham will be hoping to kick off the post Jose Mourinho era with a win when they host Southampton in the Premier League on Wednesday night.
AC Milan will be hoping to keep their faint Serie A title hopes alive when they welcome Sassuolo to San Siro on Wednesday.