Paris Saint-Germain will be aiming to stay perched atop the Ligue 1 table when they welcome 11th-placed Montpellier to Parc des Princes on Friday.
Borussia Dortmund are looking to kickstart their Ruckrunde on a positive note as they lock horns with Borussia Monchengladbach on Friday.
Real Madrid will be pushing to get back to winning ways when they face off against lower league side CD Alcoyano in the Copa del Rey on Wednesday.
Manchester City will be aiming to move to the top of the Premier League standings when they face off against Aston Villa at the Etihad Stadium this midweek.
Bayern Munich brace themselves for yet another tough challenge ahead as they face FC Augsburg in the Bavarian derby on Wednesday.
Borussia Dortmund will look to preserve their place in the Bundesliga title race as they lock horns with Bayer Leverkusen on Tuesday.
AC Milan will hope to consolidate their place atop the Serie A table when they take on Cagliari at Sardegna Arena on Monday.
Tottenham Hotspur will be looking forward to regaining their momentum in the Premier League when they face Sheffield United at Bramall Lane.
Manchester City will be hoping to close the gap to the top of the Premier League table when they welcome Crystal Palace to the Etihad on Sunday.
The first piece of silverware of the 2020/21 season in Spain will be up for grabs when Barcelona and Athletic Bilbao lock horns in the Supercopa de Espana final