Timo Werner and Mateo Kovacic are set to miss out with injuries but Cesar Azpilicueta should start when Chelsea face Leicester City in the Premier League.
Rafael Santos Borre produced a memorable performance as Eintracht Frankfurt beat Rangers to lift the UEFA Europa League.
Everton have the chance to secure safety if they manage to secure a win over Crystal Palace at Goodison Park
Burnley's bid for survival continues on Thursday as they travel to the West Midlands to face Aston Villa for the second time in less than a fortnight.
Chelsea will look to seal the third-place finish in the Premier League table when they lock horns with Leicester City on home turf this midweek.
James Milner and Joel Matip stood out as Liverpool beat Southampton 2-1 to take the Premier League title race to the final day.
Juventus threw away a 2-0 lead against Lazio on a night where Giorgio Chiellini and Paulo Dybala bid their goodbyes.
Arsenal blew their chance to finish in the top four after a lacklustre performance against Newcastle United that ended in a defeat.
Roberto Firmino will return, but Mohamed Salah and Virgil van Dijk will miss out when Liverpool and Southampton face off at St. Mary's on Tuesday.
Arsenal boss Mikel Arteta has started with his preferred centre-back partnership against Newcastle United, while Nuno Tavares and Emile Smith Rowe return.