Reece James is ruled out with a knee injury while Mateo Kovacic replaces Mason Mount in the Chelsea lineup for their home game against Arsenal.
Hector Bellerin is back in the Arsenal starting lineup, replacing Ainsley Maitland-Niles for their Premier League away game against Chelsea.
Arsenal are likely to welcome back defender Sokratis Papastathopoulos for their Premier League away game against Chelsea on Tuesday night.
Manchester City will be desperate to return to winning ways when they take on Sheffield United at Bramall Lane on Tuesday.
Chelsea youngster Reece James is expected to be fit and available for selection when Arsenal come visiting for a Premier League fixture on Tuesday night.
Both Chelsea and Arsenal will be looking to return to winning ways when they take on each other in the London Derby on Tuesday night.
Lionel Messi was the saviour for Barcelona as they kicked off the Quique Setien era with a narrow 1-0 victory over Granada on Sunday.
Nicolas Pepe was the clear standout for Arsenal, as they were held to a 1-1 draw by Sheffield United after Gabriel Martinelli's strike was cancelled out by John Fleck.
Jurgen Klopp has decided not to make any changes to the Liverpool starting XI from their win over Tottenham as they host Manchester United at Anfield.
Ole Gunnar Solskjaer has thrown in a bit of a twist with the decision to start Luke Shaw in an uncanny role in attack as Manchester United take on Liverpool.