Antonio Conte has named an unchanged side from last gameweek as Chelsea visit the Hawthorns to take on West Bromwich Albion.
Jurgen Klopp has made four changes to the side that thrashed West Ham United last time around, as Liverpool host Southampton at Anfield.
Shkodran Mustafi and Alexandre Lacazette have been recalled by Arsene Wenger as Arsenal host Tottenham at the Emirates in the North London Derby.
Jose Mourinho has been boosted by the return of three of his Manchester United players as the Red Devils host Newcastle United on Saturday.
Real Madrid make a short trip across town to the Wanda Metropolitano to face rivals Atletico Madrid, as they prepare to battle it out for third place in the La Liga table.
Tony Pulis' West Bromwich Albion host reigning champions Chelsea at the Hawthorns on Saturday, as we Premier League action returns after a long international break.
In matchweek 12 of the Premier League, reigning champions Chelsea travel to the Hawthorns to face Tony Pulis' West Bromwich Albion.
The Wanda Metropolitano prepares to host its first ever Madrid derby tonight as defending Liga champions Real Madrid take on Atletico Madrid in a battle for third place.
Ernesto Valverde will be without six first-team players as Barcelona travel to Estadio Municipal de Butarque to take on Leganes on Saturday.
Arsene Wenger could welcome Shkodran Mustafi and Danny Welbeck back into his squad when Arsenal host Tottenham at the Emirates on Saturday.