Argentina will take on Chile in a fierce South American duel at the LA Memorial Coliseum in Los Angeles on Friday
India begin their 2022 FIFA World Cup Qualification campaign in the Second Round of the Asian Qualifiers with a home fixture against Oman on Thursday.
Japan and Paraguay are set to meet each other in an international friendly, with both sides featuring for the first time since the Copa America.
Ireland will be hoping to continue their solid start to the UEFA Euro 2020 Qualifiers when they play hosts to Vladimir Petkovic's Switzerland in Dublin.
Italy will look to continue their UEFA Euro 2020 qualifying campaign as they travel to Yerevan to face Armenia on Thursday
Spain will be aiming to continue their unbeaten start to the UEFA Euro 2020 Qualifiers when they take on Romania in Bucharest on Thursday.
Lionel Messi will not be eligible to play for Argentina for the coming three months after CONMEBOL handed the Barcelona icon a three-month ban from international football.
Brazil and Peru will have the chance to become the South American champions when they face off in the Copa America final at the Maracana.
Chile and Peru will battle it out at the Arena do Gremio on Wednesday night for a place in the finals of the 2019 Copa America.
A place in the 2019 Copa America will be on the line when South American powerhouses Brazil and Argentina face off at Estadio Mineirao