Liverpool came back from being a goal down in the first-half to defeat Crystal Palace 4-3 at home to extend their lead at the top of the Premier League table.
Following a narrow defeat to Manchester United last weekend, Tottenham Hotspur will look to bounce back to winning ways as they face Fulham on Sunday
Lucas Torreira and Aaron Ramsey return to the starting eleven for Arsenal as they host Chelsea at the Emirates in a London derby.
Maurizio Sarri has decided to stick with the same lineup that earned a 2-1 win over Newcastle as Chelsea face Arsenal at Emirates.
Liverpool manager Jurgen Klopp has made three changes to the team that started against Brighton & Hove Albion, for their home game against Crystal Palace.
Ole Gunnar Solskjaer has named the same starting lineup that featured against Tottenham last week as Manchester United prepare to host Brighton & Hove Albion at Old Trafford.
Ole Gunnar Solskjaer will be without just three first-team players when Manchester United host Brighton & Hove Albion at Old Trafford on Saturday
Liverpool are likely to be without the services of Trent Alexander-Arnold and Georginio Wijnaldum, when they take on Crystal Palace this weekend.
Arsenal will look to bounce back from their London derby defeat against West Ham United when they face Chelsea in what is another derby on Saturday.
Manchester United will be aiming to continue their winning run when they welcome Brighton & Hove Albion to Old Trafford on Saturday.