A place in the UEFA Champions League final will be up for grabs when Ajax welcome Tottenham Hotspur to the Johan Cruijff ArenA in the semi-final second leg.
Barcelona will be aiming to qualify for their first UEFA Champions League final under Ernesto Valverde, when they travel to Anfield to take on Liverpool.
Real Madrid returned to winning ways on Sunday afternoon, when they defeated Javier Calleja's Villarreal side 3-2, courtesy of a Mariano Diaz double.
Chelsea booked their place in next season's UEFA Champions League, riding on a second half blitzkrieg to cruise to a 3-0 win over Watford on Sunday.
A goal from Divock Origi late in the game fired Liverpool to a crucial 3-2 win over Newcastle United at the St. James' Park on Saturday night.
Barcelona suffered their third league defeat of the season when they were handed a 2-0 loss by Celta Vigo at the Balaidos on Saturday night.
Real Madrid will be aiming to return to winning ways, when they welcome Javier Calleja's Villarreal to the Santiago Bernabeu on Sunday afternoon.
Chelsea will hope to pounce on Tottenham Hotspur's defeat to go up to third on the Premier League table when they host Watford at Stamford Bridge on Sunday.
Manchester United will be hoping to put an end to their miserable winless streak when they travel to already relegated Huddersfield on Sunday.
Barcelona will hope to continue their winning momentum ahead of their next clash with Liverpool when they take on Celta Vigo at Balaidos.