Chelsea will look to return to winning ways and keep a firm hold of the fourth place on the Premier League table when they face Newcastle United on Saturday.
Barcelona will have to come from behind to prevail in their Copa del Rey tie against Levante, plundering to a shock 2-1 loss in the first leg on Thursday
Liverpool will be hoping to overturn their mini losing run when they travel to the Amex Stadium to take on Brighton and Hove Albion on Saturday.
We take a look at some of the potentially profitable markets from the 22nd gameweek of the Premier League featuring Tottenham vs Manchester United and more.
Barcelona will be aiming to take a step closer to a place in the Copa del Rey quarter-finals when they meet Levante at the Estadi Ciutat de Valencia on Thursday
Chelsea will have it all to do in the second leg of their Carabao Cup semi-final against Tottenham, who handed them a 1-0 loss at Wembley on Tuesday.
Holders Manchester City will face off against lower league side Burton Albion in the semifinal of the Carabao Cup on Wednesday night.
It's back to back cup games for Chelsea and Tottenham, as they meet in the first leg of their Carabao Cup semi-final at Wembley on Tuesday night.
Liverpool will look to bounce back from their loss to Manchester City as they travel to face Wolves in the third round of the FA Cup on Monday night.
Chelsea were off to a winning start to the defence of their FA Cup crown on Sunday as they notched up a comfortable 2-0 win over Nottingham Forest