Liverpool are still in with a chance to snatch the Premier League title away from Manchester City and will have to win over in-form Wolves at Anfield on Sunday.
Chelsea will be hoping to finish the 2018-19 Premier League campaign with a win against Leicester City, that will guarantee them a third-place finish.
Real Madrid will hope to start building a winning momentum when they take the tricky trip to Anoeta to take on Real Sociedad on Sunday.
A victory is what Manchester City need against Brighton & Hove Albion on the final matchday, to successfully retain their Premier League title.
Manchester United will be hoping to end an agonising season on a high when they welcome Cardiff City to Old Trafford on Sunday.
Aston Villa and West Bromwich Albion are set to renew rivalries, albeit in the semi-final of the Championship Playoff, at the Villa Park on Saturday.
Sunderland and Portsmouth will be aiming to take a step closer to achieving promotion to the Championship, when they meet in the League One Playoffs first leg.
The playoff stages of the EFL Championship kick off this weekend with Derby County set to take on Leeds United in one of the semi-finals on Saturday evening.
We take a look at some of the potentially profitable markets from the 38th gameweek of the Premier League featuring Chelsea, Manchester United and more.
Tottenham completed a dramatic comeback to beat Ajax on the away goals rule, with Lucas Moura scoring in the final minute to book their place in the UEFA Champions League final.