Lionel Messi led the way for Barcelona with a fantastic hat-trick as they beat Real Betis 4-1 at the Benito Villamarin Stadium on Sunday.
Chelsea failed to make the most of their game in hand in the race for the top four, as they succumbed to a 2-0 defeat away to Everton on Sunday.
A Sadio Mane goal and a late James Milner penalty secured three points and the top spot on the Premier League table for Liverpool.
Zinedine Zidane's second coming at Real Madrid was off to a winning start, as the Merengues eased past Celta Vigo 2-0 at the Santiago Bernabeu this weekend.
Manchester United's journey in the FA Cup ended on Saturday as Wolves handed them a 2-1 defeat at Molineux to send Ole Gunnar Solskjaer & co. packing.
Barcelona will be aiming to continue consolidating their place atop the La Liga table when they travel to Estadio Benito Villamarin to face Real Betis.
Chelsea will look to go into the international break level on points with fourth-placed Arsenal, as they gear up to take on Everton on Sunday evening.
Bayern Munich will look to retain their status as league leaders as they host 1. FSV Mainz 05 at the Allianz Arena on Sunday
A place in the FA Cup semi-finals will be on the line when Manchester United face off against Wolves in their Last Eight clash at Molineux on Saturday.
Real Madrid will look to kick off Zinedine Zidane's second coming at the club with a victory, when they host relegation battlers Celta Vigo on Saturday.
