Ole Gunnar Solskjaer is expected to ring in the changes when Manchester United once again face Brighton & Hove Albion in the Carabao Cup on Wednesday.
A spot in the quarter-finals of the Carabao Cup will be on the line when Everton welcome West Ham United for the fourth round clash this week.
Manchester City will hope to get back to winning ways as they travel to Turf Moor to take on Burnley in the fourth round of the Carabao Cup.
Manchester United are hoping to advance through to the quarterfinals of the Carabao Cup as they once again face Brighton & Hove Albion on Wednesday.
Edouard Mendy will make his debut for Chelsea while Timo Werner and Ben Chilwell also start in the Carabao Cup tie against Tottenham Hotspur.
Bayern Munich and Borussia Dortmund will brace themselves for the first Der Klassiker of the season as the two teams meet in the DFL Supercup on Wednesday.
Goalkeeper Edouard Mendy is set to make his debut for Chelsea, while Ben Chilwell is in line to start when they take on Tottenham in the Carabao Cup.
It's the clash of the heavyweights in the Carabao Cup fourth round as Tottenham Hotspur play hosts to London rivals Chelsea this midweek.
An own goal from Christian Fuchs and a late strike from Eddie Nketiah helped Arsenal churn out a 2-0 Carabao Cup victory over Leicester City.
Kai Havertz and Tammy Abraham were the stars of the show, but how did the other Chelsea players fare in their 6-0 win over Barnsley in the Carabao Cup?