Top spot in Group 3 of the UEFA Nations League A will be on the line when Italy welcome Portugal to Stadio Olimpico in a Matchday 5 tie on Saturday
Two South American heavyweights clash against each other on Friday night as Brazil face off against Uruguay at the Emirates Stadium, London.
France will be hoping to book their place in the UEFA Nations League finals when they travel to Stadion Feijenoord to take on Netherlands on Friday
Wayne Rooney will pull on the England jersey for one last time, when the Three Lions host USA in an international friendly at the Wembley Stadium on Thursday.
Spain will be hoping to seal their passage to the UEFA Nations League finals when they take on Croatia at Stadion Maksimir on Thursday night.
Germany face off against fellow European nation Russia in a high-profile friendly encounter at the Red Bull Arena, Leipzig, on Thursday night.
Belgium will be aiming to get one step closer to June's UEFA Nations League finals when they host Iceland at Stade Roi Baudouin on Thursday.
Switzerland will be hoping to get their preparations for the UEFA Nations League Matchday 6 in order when they play Qatar at Stadio di Cornaredo
Bitter rivals Belgium and Netherlands are set to clash in the Derby der Lage Landen at King Baudouin Stadium on Tuesday night.
Group 4 of UEFA Nations League B could be blown wide open when Republic of Ireland welcome Wales to the Aviva Stadium in Dublin on Tuesday