Barcelona will look to build on their victory over Juventus when they take on Deportivo Alaves at the Estadio Mendizorroza on Saturday.
Borussia Dortmund will hope to keep their winning run alive as they take on Arminia Bielefeld at the Schüco-Arena in gameweek six of the Bundesliga.
Hakim Ziyech impressed on full debut while Kai Havertz maintained his good form as Chelsea registered their first Champions League win of the season.
Tottenham Hotspur will hope to continue their winning run alive when they take on Royal Antwerp in their second UEFA Europa League game on Thursday.
Mason Mount and Mateo Kovacic are expected to return to the lineup when Chelsea take on FC Krasnodar in a UEFA Champions League Group E tie on Wednesday.
Atalanta will be hoping to build on their impressive victory in the Champions League from last week as they get ready to host Ajax.
Real Madrid are reportedly not ready to hand captain Sergio Ramos a new two-year deal as his current contract comes close to expiration.
Joe Gomez ended the game as the only standout performer as Liverpool hosted Sheffield United in a narrow 2-1 win.
Neto's goalkeeping masterclass could only help Barcelona so much as they fell to a 3-1 defeat against Real Madrid on Saturday.
Fabinho is set to retain his place as the centre-back while Thiago comes in to screen the defence when Liverpool host Sheffield United on Saturday.