Real Madrid will be aiming to move to the top of the La Liga standings when they face off against relegation battlers RCD Espanyol at home on Saturday afternoon.
Chelsea will be hoping to close down the gap to third-placed Manchester City when they clash against a struggling Everton side at Goodison Park on Saturday.
Inter Milan will be aiming to strengthen their position at the top of the Serie A table when they host fifth-placed AS Roma on Friday night.
Manchester City are reportedly set to join La Liga champions Barcelona in pursuit of Inter Milan's Argentine striker Lautaro Martinez.
Manchester United will be hoping to recall Scott McTominay to the starting XI when they host former boss Jose Mourinho's Tottenham outfit on Wednesday.
Jose Mourinho will return to Old Trafford for the first time since being sacked by Manchester United, as his Tottenham side take on the Red Devils this week.
Manchester United are reportedly plotting a winter window swoop for Barcelona midfielder Arturo Vidal, who is unhappy with his situation in Spain.
Manchester City will be intent on getting back to winning ways when they travel to Turf Moor to take on Burnley on Tuesday night in then Premier League.
Juventus manager Maurizio Sarri is reportedly seeking a reunion with Chelsea star Emerson Palmieri in the next summer transfer window.
Tottenham Hotspur will be looking to make it three wins in three under new boss Jose Mourinho, when they take on AFC Bournemouth on Saturday.