In-form Arsenal travel to Turf Moor to face Burnley. Burnley have been winless in the last seven games against the Gunners.
Stoke City make the journey to Manchester to face Manchester United at Old Trafford. Jose Mourinho's side has won all eight previous home fixtures against Stoke.
Ukrainian outfit Zorya Luhansk travel to Old Trafford to take on Manchester United in the Europa League.
European powerhouse Barcelona travel to Germany to face Borussia Monchengladbach. This is the first time the two teams will play each other.
FC Basel travels to London to meet the Gunners. This is the first time they will be playing each other. While Arsenal have won all their previous encounters with Swiss clubs, Basel have lost only one of their matches against English opposition -- Manchester United in 2002.
Defending champions Real Madrid go up against German giants Borussia Dortmund in the UEFA Champions League tonight. Group stage matches rarely comes bigger than this.